Author/Editor		Rades, Dirk; Dziggel, Liesa; Nagy, Viorica; Šegedin, Barbara; Lohynska, Radka; Veninga, Theo; Khoa, Mai T.; Trang, Ngo T.; Schild, Steven E.
Title		#A #new survival score for patients with brain metastases who received whole-brain radiotherapy (WBRT) alone
Type		članek
Vol. and No.		Letnik 108, št. 1
Publication year		2013
Volume		str. 123-127
ISSN		0167-8140 - Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology
Language		eng
Abstract		Background and purpose Survival scores for patients with brain metastasis exist. However, the treatment regimens used to create these scores were heterogeneous. This study aimed to develop and validate a survival score in homogeneously treated patients. Materials and methods Eight-hundred-and-eighty-two patients receiving 10 3 Gy of WBRT alone were randomly assigned to a test group (N = 441) or a validation group (N = 441). In the multivariate analysis of the test group, age, performance status, extracranial metastasis, and systemic treatment prior to WBRT were independent predictors of survival. The score for each factor was determined by dividing the 6-month survival rate (in %) by 10. Scores were summed and total scores ranged from 6 to 19 points. Patients were divided into four prognostic groups. Results The 6-month survival rates were 4% for 69 points, 29% for 1014 points, 62% for 1517 points, and 93% for 1718 points (p < 0.001) in the test group. The survival rates were 3%, 28%, 54% and 96%, respectively (p < 0.001) in the validation group. Conclusions Since the 6-month survival rates in the validation group were very similar to the test group, this new score (WBRT-30) appears valid and reproducible. It can help making treatment choices and stratifying patients in future trials.
Keywords		radioterapija metastaze možgani nevrokirurgija preživetje brain metastases survival radiotherapy