Author/Editor | Rades, Dirk; Dziggel, Liesa; Šegedin, Barbara; Oblak, Irena; Nagy, Viorica; Marita, Andreea; Schild, Steven E. | |
Title | The first survival score for patients with brain metastases from small cell lung cancer (SCLC) | |
Type | članek | |
Vol. and No. | Letnik 115, št. 10 | |
Publication year | 2013 | |
Volume | str. 2029-2032 | |
ISSN | 0303-8467 - Clinical neurology and neurosurgery | |
Language | eng | |
Abstract | OBJECTIVE: Survival scores can help physicians select appropriate treatment for patients with brain metastasis. Primary tumors have different biological behavior justifying separate scoring systems for different tumors. In this study, a survival score was developed for patients with brain metastasis from SCLC. METHODS: Data of 172 patients receiving whole-brain radiotherapy alone for brain metastasis from SCLC were included. Patients were assigned to a test (N=86) or a validation group (N=86). In the test group, Karnofsky Performance Score, number of brain metastases, and extracranial metastasis were associated with survival and included in the score. Scores for each factor were obtained from the 6-month survival rate divided by 10. According to the total scores, which represented the sum of the three scores, three prognostic groups were formed. RESULTS: 6-Month survival rates in the test group were 3% for 5-8 points, 40% for 9-12 points, and 89% for 15 points (p<0.001). In the validation group, 6-month survival rates were 3%, 41%, and 89% (p<0.001). The comparisons between the three prognostic groups of the test group and the validation group did not show significant differences. CONCLUSIONS: This new score appears valid and reproducible. It can be used to personalize the treatment to patients with brain metastasis from SCLC. | |
Keywords | metastaze možgani drobnocelični rak preživetje brain metastasis scoring system small-cell lung cancer survival prognosis |