Avtor/Urednik		Hauptman, Nina; Glavač, Damjan
Naslov		MicroRNAs and long non-coding RNAs
Tip		članek
Vir		In: Articles from 7th Conference of experimental and translational oncology, [April, 20-24, 2013, Portorož] Ljubljana : Association of Radiology and Oncology
Leto izdaje		2013
Obseg		str. 311-318
Jezik		eng
Abstrakt		Background. Non-coding RNAs (ncRNAs) are key regulatory molecules in cellular processes, and are potentialbiomarkers in many diseases. Currently, microRNAs and long non-coding RNAs are being pursued as diagnostic andprognostic biomarkers, and as therapeutic tools in cancer, since their expression profiling is able to distinguish differentcancer types and classify their sub-types. Conclusions. There are numerous studies confirming involvement of ncRNAs in cancer initiation, development andprogression, but have only been recently identified as new diagnostic and prognostic tools. This can be beneficialin future medical cancer treatment options, since ncRNAs are natural antisense interactors included in regulationof many genes connected to survival and proliferation. Research is directed in development of useful markers fordiagnosis and prognosis in cancer and in developing new RNA-based cancer therapies, of which some are alreadyin clinical trials.
Proste vsebinske oznake		microRNAs long non-coding RNAs biomarker microRNAs dolge nekodirane RNA molekule biomarker