Avtor/Urednik		Pickwell, Kristy M.; Siersma, V.; Kars, Marleen; Holstein, Per E.; Schaper, Nicholaas; Urbančič-Rovan, Vilma
Naslov		Diabetic foot disease
Tip		članek
Leto izdaje		2013
Obseg		str. 377-383
ISSN		1520-7552 - Diabetes/metabolism research and reviews
Jezik		eng
Abstrakt		BackgroundHealing of heel ulcers in patients with diabetes is considered to be poor, but there is relatively little information on the influence of ulcer location on ulcer healing. MethodsThe influence of ulcer location on time to healing of diabetic foot ulcers was analysed by multivariate Cox regression analysis for 1000 patients included in the Eurodiale study, a prospective cohort study of patients with diabetic foot disease. ResultsMedian time to healing was 147days for toe ulcers [(95% confidence interval (CI) 135159days)], 188days for midfoot ulcers (95% CI 158218days) and 237days for heel ulcers (95% CI 205269days) (p<0.01). The median time to healing for plantar ulcers was 172days (95% CI 157187days) and 155days (95% CI 138172days) for nonplantar ulcers (p=0.71). In multivariate Cox regression analysis, the hazard ratio for ulcer healing for midfoot and heel ulcers compared with toe ulcers was 0.77 (95% CI 0.640.92) and 0.62 (95% CI 0.470.83), respectively; the hazard ratio for ulcer healing for plantar versus nonplantar ulcers was 1 (95% CI 0.841.19). Other factors significantly influencing time to healing were the duration of diabetes, ulcer duration, the presence of heart failure and the presence of peripheral arterial disease. ConclusionsTime to ulcer healing increased progressively from toe to midfoot to heel, but did not differ between plantar and nonplantar ulcers. Our data also indicate that risk factors for longer time to healing differ from factors that affect the ultimate number of ulcers that heal (healing rate).
Proste vsebinske oznake		diabetic foot disease ulcer