Avtor/Urednik		Cereda, Matteo; Pozzoli, Uberto; Rot, Gregor; Juvan, Peter; Schweitzer, Anthony C.; Clark, Tyson; Ule, Jernej
Naslov		RNAmotifs
Tip		članek
Vol. in št.		Letnik 15, št. 1
Leto izdaje		2014
Jezik		eng
Abstrakt		RNA-binding proteins (RBPs) regulate splicing according to position-dependent principles, which can be exploited for analysis of regulatory motifs. Here we present RNAmotifs, a method that evaluates the sequence around differentially regulated alternative exons to identify clusters of short and degenerate sequences, referred to as multivalent RNA motifs. We show that diverse RBPs share basic positional principles, but differ in their propensity to enhance or repress exon inclusion. We assess exons differentially spliced between brain and heart, identifying known and new regulatory motifs, and predict the expression pattern of RBPs that bind these motifs. RNAmotifs is available at https://bitbucket.org/rogrro/rna_motifs.
Proste vsebinske oznake		multivalent RNA motifs RNA-binding proteins alternative splicing multivalentni RNA motivi RNA-vezavni proteini alternativni prepleti