Author/Editor		Slaughter, Mark S.; Gregorič, Igor
Title		HeartWare ventricular assist system for bridge to transplant
Type		članek
Vol. and No.		Letnik 32, št. 7
Publication year		2013
Volume		str. 675-683
ISSN		1053-2498 - The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation
Language		eng
Abstract		Background The HeartWare Ventricular Assist System (HeartWare Inc, Framingmam, MA) is a miniaturized implantable, centrifugal design, continuous-flow blood pump. The pivotal bridge to transplant and continued access protocols trials have enrolled patients with advanced heart failure in a bridge-to-transplant indication. Methods The primary outcome, success, was defined as survival on the originally implanted device, transplant, or explant for ventricular recovery at 180 days. Secondary outcomes included an evaluation of survival, functional and quality of life outcomes, and adverse events. Results A total of 332 patients in the pivotal bridge to transplant and continued access protocols trial have completed their 180-day primary end-point assessment. Survival in patients receiving the HeartWare pump was 91% at 180 days and 84% at 360 days. Quality of life scores improved significantly, and adverse event rates remain low. Conclusions The use of the HeartWare pump as a bridge to transplant continues to demonstrate a high 180-day survival rate despite a low rate of transplant. Adverse event rates are similar or better than those observed in historical bridge-to-transplant trials, despite longer exposure times due to longer survival and lower transplant rates.
Keywords		heart failure quality of life survival odpoved srca kvaliteta življenja preživetje