Avtor/Urednik		Gerdan, Lavinia; Šegedin, Barbara; Nagy, Viorica; Khoa, Mai T.; Trang, Ngo T.; Schild, Steven E.; Rades, Dirk
Naslov		The number of involved extracranial organs
Tip		članek
Vol. in št.		Letnik 115, št. 10
Leto izdaje		2013
Obseg		str. 2108-2110
ISSN		0303-8467 - Clinical neurology and neurosurgery
Jezik		eng
Abstrakt		OBJECTIVE: This study was performed to investigate the potential impact of the number of involved extracranial organs on survival in patients with brain metastasis from breast cancer. METHODS: The data of 196 patients treated with whole-brain radiotherapy (WBRT) alone for brain metastases from breast cancer were retrospectively analyzed. Six potential prognostic factors were evaluated for associations with survival. These factors included WBRT regimen, age, Karnofsky performance score (KPS), number of brain metastases, interval from breast cancer diagnosis to WBRT, and the number of involved extracranial organs. RESULTS: The 6-month survival rates of patients with involvement of 0, 1, 2, 3 and %4 extracranial organs were 59%, 49%, 26%, 26% and 13%, respectively, and the 12-month survival rates were 45%, 36%, 17%, 17% and 13%, respectively (p<0.001). On multivariate analysis, the number of involved extracranial organs (risk ratio 1.17; 95%-confidence interval 1.02-1.35; p=0.028) maintained significance, as did KPS (p<0.001), but not age (p=0.27). CONCLUSION: The number of involved extracranial organs is an independent prognostic factor of survival in patients with brain metastasis from breast cancer.
Proste vsebinske oznake		možganske metastaze rak dojke ekstrakranialni organi preživetje brain metastasis breast cancer extracranial organs survival