Avtor/Urednik		Goričar, Katja; Kovač, Viljem; Dolžan, Vita
Naslov		Polymorphisms in translesion polymerase genes influence treatment outcome in malignant mesothelioma
Tip		članek
Vol. in št.		Letnik 15, št. 7
Leto izdaje		2014
Obseg		str. 941-951
ISSN		1462-2416 - Pharmacogenomics
Jezik		eng
Abstrakt		Aim: We evaluated the influence of genetic variability in translesion polymerases REV1 and REV3L on the outcome of cisplatin treatment in malignant mesothelioma patients. Materials & methods: ln total, 139 malignant mesothelioma patients were genotyped for seven tag SNPs in REV1 and REV3L. Logistic regression and Cox regression were used to assess the influence of SNPs on treatment outcome. Results: Polymorphic REV1 rs3087403 allele and REV1 TGT haplotype were associated with increased rISk for leukopenia (p = 0.013 and p = 0.047, respectively) and neutropenia (p = 0.048 and p = 0.024, respectively). REV3L rs465646, rs462779 and REV3L CCGG haplotype were significantly associated with longer overall survival (p = 0.007, P = 0.022 and p = 0.013, respectively). Conclusion: Our results suggest for the first time that REV1 and REV3L SNPs might serve as potential predictive markers of outcome of cisplatinbased chemotherapy.
Proste vsebinske oznake		polymorphisms polymerase genes malignant mesothelioma polimorfizmi polimerazo genov maligni mezoteliom