Author/Editor		Glavač, D; Ravnik-Glavač, M; O'Brien, SJ; Dean, M
Title		Polymorphisms in the 3' untranslated region of the I kappa B/MAD-3 (NFKBI) gene located on chromosome 14
Type		članek
Source		Hum Genet
Vol. and No.		Letnik 93, št. 6
Publication year		1994
Volume		str. 694-6
Language		eng
Abstract		The NF-kappa B transcription factor regulates the expression of a number of genes, including immune function and growth control loci, and several viruses. For example, the long terminal repeat of the human immunodeficiency virus contains NF-kappa B binding sites. NF-kappa B activity in the nucleus is regulated by a cellular inhibitory protein I kappa B. To analyze the potential role of these genes in genetic disease we have mapped the NF-kappa B (NFKB2) and I kappa B/MAD-3 (NFKBI) loci in a panel of somatic cell hybrids to chromosomes 4 and 14, respectively. Amplification of the 3' untranslated region of NFKBI allows the detection of three independent polymorphisms within 410 bp. In combination these polymorphisms were informative in 27 of 36 CEPH families and allowed the gene to be placed onto the linkage map of chromosome 14, between the D14S32 and D14S42 markers.
Descriptors		CHROMOSOMES, HUMAN, PAIR 14 DNA-BINDING PROTEINS NF-KAPPA B POLYMORPHISM (GENETICS) TRANSLATION, GENETIC BASE SEQUENCE DNA PRIMERS LINKAGE (GENETICS) MOLECULAR SEQUENCE DATA