Avtor/Urednik		Roblek, Tina; Trobec, Katja; Mrhar, Aleš; Lainščak, Mitja
Naslov		Potential drug-drug interactions in hospitalized patients with chronic heart failure and chronic obstructive pulmonary disease
Tip		članek
Vol. in št.		Letnik 10, št. 5
Leto izdaje		2014
Obseg		str. 920-932
ISSN		1734-1922 - Archives of medical science : AMS
Jezik		eng
Abstrakt		Introduction: Polypharmacy is common in patients with chronic heart failure (HF) and/or chronic obstructive pulmonary disease (COPD), but little is known about the prevalence and significance of drug-drug interactions (DDIs). This study evaluates DDIs in hospitalized patients. Material and methods: We retrospectively screened medical charts over a 6-month period for diagnosis of chronic HF and/or COPD. Potential DDIs were evaluated using Lexi-Interact software. Results: Seven hundred and seventy-eight patients were included in the study (median age 75 years, 61% men). The median number of drugs on admission and discharge was 6 (interquartile range (IQR) 4-9) and 7 (IQR 5-), respectively (p = 0.10). We recorded 6.5 +-5.7 potential DDIs per patient on admission and 7.2 +-5.6 on discharge (p = 0.2). From admission to discharge, type-C and type-X potential DDIs increased (p < 0.05 for both). Type X interactions were rare (< 1%), with the combination of a ß-blocker and a ß2 agonist being the most common (64%). There were significantly more type-C and type-D potential DDIs in patients with chronic HF as compared to patients with COPD (p < 0.001). Patients with concomitant chronic HF and COPD had more type-C and type-X potential DDIs when compared to those with individual disease (p < 0.005). An aldosterone antagonist and ACE inhibitor/ ARB were prescribed to 3% of chronic HF patients with estimated glomerular filtration rate < 30 ml/(min x 1.73 m2). Conclusions: The DDIs are common in patients with chronic HF and/or COPD, but only a few appear to be of clinical significance. The increase in potential DDIs from admission to discharge may reflect better guideline implementation rather than poor clinical practice.
Proste vsebinske oznake		potential drug-drug interactions chronic heart failure chronic obstructive pulmonary disease statistical analysis