Avtor/Urednik		Sedej, Katarina; Rožman, Primož
Naslov		Novosti pri zdravljenju z gensko terapijo
Prevedeni naslov		New developments in gene therapy
Tip		članek
Vol. in št.		Letnik 83, št. 11
Leto izdaje		2014
Obseg		str. 802-813
ISSN		1581-0224 - Zdravniški vestnik
Jezik		slv
Abstrakt		Gene therapy is the treatment of genetic disor - ders by introducing genetic material into cells. For this purpose, viral vectors and non-viral methods for introducing genes into cells are used, the later being in general less effective. After the enthusiastic beginings in 1990, gene ther - apy came to a standstill due to side effects of ad - enoviral vectors during gene therapy and when several patients developed leukemia. Nowadays, many studies are testing clinical efficacy of gene therapy to cure cancer, monogenetic disorders and cardiovascular deseases. In last few years we witnessed successful treatments of some patients with severe immune deficiency, Leber's congeni - tal amaurosis, thalassaemia and adrenoleuko - dystrophy. Recently, approval of the first gene therapy by European authorities was reported. It seems that gene therapy, regardless of the rela - tive delay in the 90's, is coming into forefront of advanced therapies.
Proste vsebinske oznake		genska terapija dedne genetske bolezni vektorji pri genski terapiji gene therapy inherited genetic disease vectors for gene therapy