Author/Editor		Filipič, M; Lovinčič, D; Erjavec, M; Glavič, D; Šek, S; Planina, P; Klun, N; Vrhovšek, M; Kraigher, A; Kotnik, A; Jan, J
Title		Monitoring for genotoxic and toxic substances in surface water
Type		članek
Source		In: International symposium on environmental contamination in central and eastern Europe. A forum for technology transfer: symposium proceedings; 1992 Oct 12-16; Budapest,
Publication year		1992
Volume		str. 520-2
Language		eng
Abstract		The purpose of the study was to determine the incidence of vesicoureteral reflux (VUR), renal scars and hypertension in asymptomatic siblings of children with VUR. 105 siblings of patients with VUR were studied. Their age ranged from 4 months to 6 years and 4 months. Ali had a direct radionuclide voiding cystography (DRVC) performed. VUR was detected in 47/105 (45 percent). Most high grade VURs were seen within the first year of age, their incidence being 50 percent compared with only 9 percent in siblings older than 2 years. Only 1 or the 27 siblings with VUR grade 1 was younger than 1 year. In 43 of 47 siblings with VUR, 99mTc-DMSA was performed and renal scars were found in 10, which presents 23 percent of siblings with VUR and 10 percent of all siblings studied. One child had hypertension. Early identifying VUR among asymptomatic siblings could possibly prevent renal damage and its consequences. The predictive value of positive family history alone in identifying VUR was 45 percent and 23 percent of siblings with VUR were found to have renal scars. This appears high enough to justify the routine investigation of asymptomatic siblings, by using DRVC at an early age. Health risk assessment based on data for single chemicals is limited by number of chemicals that can be identified in water for which toxicity data are not available. Besides, prediction of biological effects of interactions between chemicals is difficult or impossible on the basis of data for single chemicals. Genotoxicity and toxicity of water samples taken from different chosen sites were pollution was expected was monitored. For the same samples physical, chemical and microbiological analysis were conducted according to the routine water quality control. For determination of genotoxic activity water sample concentrates were tested with Salmonella typhimurium TA 98 and TA 100 and Escherichia coli MP2(pKM101) and WP2(pKM101)uvrA with and without exogenous metabolic activation.(trunc.)
Descriptors		WATER POLLUTANTS, CHEMICAL MUTAGENICITY TESTS SALMONELLA TYPHIMURIUM ESCHERICHIA COLI