Author/Editor		Štalc, A
Title		Changes in the membrane lipid domains and their significance in pharmacology and toxicology
Type		članek
Source		Studia biophysica
Vol. and No.		Letnik 138, št. 1-2
Publication year		1990
Volume		str. 71-8
Language		eng
Abstract		There are many drugs which influence directly or indirectly on the cell membrane, whether mammalian or non-mammalian. The drug may disrupt the membrane in such a way that it becomes highly permeable; either by influencing the interaction between phospholipids and proteins or by forming complexes between ligands and sterols. Many substances change membrane lipid fluidity and consequently they can affect receptor and enzyme function on both static dynamic level. How efficiently the drug pass through the lipid portion of the membrane, can also be essentially contribute to the action of some drugs. In the present work a considerable effort is intended especially to study of some cholinergic substances.
Descriptors		LIPID BILAYERS MEMBRANE FLUIDITY RATS TORPEDO ELECTRIC ORGAN ERYTHROCYTE MEMBRANE ORGANOPHOSPHORUS COMPOUNDS ANESTHETICS, GENERAL ANTI-INFLAMMATORY AGENTS PROPRANOLOL TUMOR NECROSIS FACTOR PARATHION