Avtor/Urednik		Heneka, Michael T; Carson, Monica J; Khoury, Joseph El; Brosseron, Frederic; Feinstein, Douglas L; Jacobs, Andreas H; Wyss-Coray, Tony; Vitorica, Javier; Ransohoff, Richard M; Verkhratsky, Alexei
Naslov		Neuroinflammation in Alzheimer's disease
Tip		članek
Vol. in št.		Letnik 14, št. 4
Leto izdaje		2015
Obseg		str. 388-405
ISSN		1474-4422 - Lancet neurology
Jezik		eng
Abstrakt		Increasing evidence suggests that Alzheimer's disease pathogenesis is not restricted to the neuronal compartment, but includes strong interactions with immunological mechanisms in the brain. Misfolded and aggregated proteins bind to pattern recognition receptors on microglia and astroglia, and trigger an innate immune response characterised by release of infl ammatory mediators, which contribute to disease progression and severity. Genome-wide analysis suggests that several genes that increase the risk for sporadic Alzheimer's disease encode factors that regulate glial clearance of misfolded proteins and the infl ammatory reaction. External factors, including systemic infl ammation and obesity, are likely to interfere with immunological processes of the brain and further promote disease progression. Modulation of risk factors and targeting of these immune mechanisms could lead to future therapeutic or preventive strategies for Alzheimer's disease.
Proste vsebinske oznake		Alzheimer's disease brain immunological mechanisms Alzheimerjeva bolezen možgani imunski mehanizmi