Avtor/Urednik		Reyes, Reno C.; Verkhratsky, Alexei; Parpura, Vladimir
Naslov		TRPC1-mediated Ca2[sup]+ and Na[sup]+ signalling in astroglia
Tip		članek
Vol. in št.		Letnik 55, št. 2
Leto izdaje		2013
Obseg		str. 120-125
ISSN		0143-4160 - Cell calcium
Jezik		eng
Abstrakt		Canonical transient receptor potential 1 (TRPC1) plasmalemmal cation channels mediate Ca2+ and Na+ fluxes and control respective cytoplasmic ion signals in rat cortical astrocytes. Mechanical stimulation of astrocytes results in an increase in the levels of cytosolic Ca2+ and Na+ that are in part due to entry of extracellular cations through TRPC1 containing channels. Inhibition of the TRPC1 pore with an antibody against its selective filter reduced cytosolic Ca2+ accumulation caused by mechanical stimulation. In contrast, this immunological treatment increased the cytosolic Na+ peak accumulation induced by mechanical stimulation. We propose that TRPC channels are amenable to changes in selective filtering, as mutations in previous studies and antibody binding in our present study differentially affect the flux of Ca2) and Na+. TRPC1 containing channels might represent focal points for co-ordination of Ca2+ and Na+ signalling in astroglia and this can have consequences on Ca(2+)- and Na(+)-dependent processes such as regulated exocytosis and lactate production, respectively, which in turn can modulate neuronal synaptic transmission.
Proste vsebinske oznake		astrocyte calcium sodium astrocit kalcij natrij