Avtor/Urednik		Rodríguez, José J.; Verkhratsky, Alexei
Naslov		Neuroglial roots of neurodegenerative diseases?
Tip		članek
Vol. in št.		Letnik 43, št. 2
Leto izdaje		2011
Obseg		str. 87-96
ISSN		0893-7648 - Molecular neurobiology
Jezik		eng
Abstrakt		Neuroglia is critically important for controlling the brain homeostasis and for mounting the brain defence against pathological insults. Here, we overview recent data about the role of neuroglia in various types of neurodegenerative diseases (Alzheimer's disease, Parkinson's disease, fronto-temporal dementia, Wernicke encephalopathy, amyotrophic lateral sclerosis and immunodeficiency virus-1-associated dementia). In all these forms of neurodegeneration, astroglia undergoes complex morphological and functional changes. The early and mid-term stages of neurodegenerative processes, and specifically of Alzheimer's disease, are associated with generalised atrophy of astroglia, whereas the later stages are characterised with an astrogliosis and microglial activation linked to neuropathological lesions such as senile plaques. Atrophic changes in astroglia may contribute to the initial cognitive deficits due to reduced glial synaptic coverage and decreased neuroprotection.
Proste vsebinske oznake		astrocytes Alzheimer's disease neurodegeneration astrociti Alzheimerjeva bolezen nevrodegeneracija