Author/Editor		Žemva, A; Žemva, Ž; Jelenc, M
Title		Is insulin arrhythmogenic?
Type		članek
Source		New trends in arrhythmias
Vol. and No.		, št. 2
Publication year		1994
Volume		str. 527-30
Language		eng
Abstract		We stuied a consecutive series of 46 nondiabetic men with hyperinsulinaemia due to hypertension, who were referred to our clinic for evaluation of ventricular and supraventricular ectopic beats. A group of 42 men with normal insulin served as control. Fasting insulin levels were determined by radioimmunoassay. The frequency of ectopic beats was assessed by 24 hours Holter monitoring. A positive correlation of fasting insulin with occurence of ventricular (r = 0.495, p less th. 0.05) and supraventricular ectopic beats (r = 0.57, p less th. 0.01) was found. Increased ectopic activity could be explained by several changes induced by hyperinsulinemia, which are potentially arrhythmogenic: enhanced sympathetic activity, increased secretion of catecholamines and interference with several transmembrane exchange systems of sodium, potassium, calcium and magnesium.
Descriptors		INSULIN EXTRASYSTOLE ELECTROCARDIOGRAPHY, AMBULATORY HYPERTENSION INSULIN RESISTANCE