Avtor/Urednik		Južnič Šetina, Tanja; Borštnar, Simona; Jezeršek Novaković, Barbara
Naslov		Outcomes of treatment in Slovene follicular lymphoma patients
Tip		članek
Vol. in št.		Letnik 15, št. 10
Leto izdaje		2015
Obseg		str. 586-591
ISSN		2152-2650 - Clinical lymphoma, myeloma & leukemia
Jezik		eng
Abstrakt		The outcome of follicular lymphoma (FL) patients has dramatically improved over the last two decades by introduction of rituximab (R) in combination chemotherapy and into maintenance setting. We retrospectively analyzed the treatment outcomes in Slovene FL patients in the era of rituximab and compare them to the results reported by pivotal clinical studies. Patients and Methods: Two hundred and seventy-eight patients with FL treated in Slovenia between 2000 and 2010, with a median follow-up of 5.7 years were included in our retrospective analysis. One hundred ninetythree (69%) of them received systemic treatment (ST). Results: With a median follow-up of 5.7 years, the 5- and 10-year overall survival (OS) rates for the whole series were 77% and 53%, respectively. The 5-year progression-free survival (PFS) for 193 FL patients treated with ST was 37%. Patients treated with R-chemotherapy had a significantly better OS than patients treated with chemotherapy alone with a 5-year OS of 79% versus 53% (HR 0.39, 95% CI 0.22-0.67, p=0.001). Adding rituximab to the first-line chemotherapy significantly improved PFS compared to chemotherapy alone (HR=0.26; 95% CI 0.18-0.36, p<0.001). Maintenance rituximab after immunochemotherapy in first-line treatment reduced the risk for progression by 61% and significantly prolonged the time to progression (HR=0.39; 95% CI 0.20- 0.73, p<0.003). Conclusions: The outcomes in our routinely treated FL patients confirm the benefit of adding rituximab to chemotherapy and are comparable to the results of pivotal clinical studies. The outcome of our FL patients was improved in terms of both PFS and OS.
Proste vsebinske oznake		folikularni limfom rituksimab kemoterapija limfomi folikularni limfom rituximab chemotherapy