Avtor/Urednik		Rades, Dirk; Šegedin, Barbara; Perpar, Ana
Naslov		Radiotherapy with 4 Gy x 5 versus 3 Gy x 10 for metastatic epidural spinal cord compression
Tip		članek
Vol. in št.		Letnik 34, št. 6
Leto izdaje		2016
Obseg		str. 597-602
ISSN		0732-183X - Journal of clinical oncology : official journal of the American Society of Clinical Oncology
Jezik		eng
Abstrakt		To compare short-course radiotherapy (RT) (4 Gy x 5) to longer-course RT (3 Gy x 10) for metastatic epidural spinal cord compression (MESCC). PATIENTS AND METHODS: Two-hundred three patients with MESCC and poor to intermediate expected survival were randomly assigned to 4 Gy x 5 in 1 week (n = 101) or 3 Gy x 10 in 2 weeks (n = 102). Patients were stratified according to ambulatory status, time developing motor deficits, and primary tumor type. Seventy-eight and 77 patients, respectively, were evaluable for the primary end point, 1-month overall response regarding motor function defined as improvement or no further progression of motor deficits. Other study end points included ambulatory status, local progression-free survival, and overall survival. End points were evaluated immediately after RT and at 1, 3, and 6 months thereafter. RESULTS: At 1 month, overall response rates regarding motor function were 87.2% after 4 Gy x 5 and 89.6% after 3 Gy x 10 (P = .73). Improvement rates were 38.5% and 44.2%, respectively, no further progression rates 48.7% and 45.5%, respectively, and deterioration rates 12.8% and 10.4%, respectively (P = .44). Ambulatory rates at 1 month were 71.8% and 74.0%, respectively (P = .86). At other times after RT, the results were also not significantly different. Six-month local progression-free survival was 75.2% after 4 Gy x 5 and 81.8% after 3 Gy x 10 (P = .51); 6-month overall survival was 42.3% and 37.8% (P = .68).
Proste vsebinske oznake		klinične študije radioterapija preživetje clinical trials radiotherapy survival