Avtor/Urednik		Nkiwane, Karen S.; Pötter, Richard; Fokdal, Lars U.; Hoskin, Peter J.; Pearcey, Robert; Šegedin, Barbara; Mahantshetty, Umesh; Kirisits, Christian
Naslov		Use of bladder dose points for assessment of the spatial dose distribution in the posterior bladder wall in cervical cancer brachytherapy and the impact of applicator position
Tip		članek
Vol. in št.		Letnik 14, št. 2
Leto izdaje		2015
Obseg		str. 252-259
ISSN		1538-4721 - Brachytherapy
Jezik		eng
Abstrakt		To validate the feasibility and use of dose points to characterize the bladder wall dose distribution and investigate potential impact of the applicator position in cervical cancer brachytherapy. METHODS AND MATERIALS: One hundred twenty-eight optimized MRI plans were evaluated. The International Commission of Radiation Units and Measurements (ICRU-38) point doses (B(ICRU)), surrogate for bladder base doses, were compared with D(2cc). Vaginal source to superior-anterior border of the symphysis distances were measured and compared within two groups, namely Group 1-B(ICRU)/D(2cc) %1 and Group 2-B(ICRU)/D(2cc) <1. Additionally, points at 1.5 and 2 cm cranial to the B(ICRU), parallel to the tandem and the body axis were analyzed.% % RESULTS: % % Thirty-seven percent of the patients had the ratio B(ICRU)/D(2cc) of 1 or higher, with the 2cc subvolume at the bladder base (Group 1). In 63%, BICRU/D2cc ratio was lower than 1 and the 2cc, cranial to the bladder base (Group 2). Median vaginal source-to-superior-anterior border of the symphysis line distance was -2 cm (range, -3.7 to +1.2 cm) in Group 1 and +1.8 cm (range, -2 to +4.8 cm) in Group 2 (+ cranial/- caudal direction). There was a high correlation between vaginal sources near the symphysis and the 2cc subvolume at the bladder base. The additional points provided no added value.
Proste vsebinske oznake		brahiterapija rak materničnega vratu magnetna resonanca 3D MRI brachytherapy cervical cancer applicator position