Avtor/Urednik		Rades, Dirk; Huttenlocher, Stefan; Šegedin, Barbara; Perpar, Ana; Conde-Moreno, Antonio J.; Garcia, Raquel; Veninga, Theo; Stalpers, Lukas J. A.; Cacicedo, Jon; Rudat, Volker; Schild, Steven E.
Naslov		Single-fraction versus 5-fraction radiation therapy for metastatic epidural spinal cord compression in patients with limited survival prognoses
Tip		članek
Vol. in št.		Letnik 93, št. 2
Leto izdaje		2015
Obseg		str. 368-372
ISSN		0360-3016 - International journal of radiation oncology, biology, physics
Jezik		eng
Abstrakt		This study compared single-fraction to multi-fraction short-course radiation therapy (RT) for symptomatic metastatic epidural spinal cord compression (MESCC) in patients with limited survival prognosis. METHODS AND MATERIALS. A total of 121 patients who received 8 Gy x 1 fraction were matched (1:1) to 121 patients treated with 4 Gy x 5 fractions for 10 factors including age, sex, performance status, primary tumor type, number of involved vertebrae, other bone metastases, visceral metastases, interval between tumor diagnosis and MESCC, pre-RT ambulatory status, and time developing motor deficits prior to RT. Endpoints included in-field repeated RT (reRT) for MESCC, overall survival (OS), and impact of RT on motor function. Univariate analyses were performed with the Kaplan-Meier method and log-rank test for in-field reRT for MESCC and OS and with the ordered-logit model for effect of RT on motor function. RESULTS: Doses of 8 Gy x 1 fraction and 4 Gy x 5 fractions were not significantly different with respect to the need for in-field reRT for MESCC (P=.11) at 6 months (18% vs 9%, respectively) and 12 months (30% vs 22%, respectively). The RT regimen also had no significant impact on OS (P=.65) and post-RT motor function (P=.21). OS rates at 6 and 12 months were 24% and 9%, respectively, after 8 Gy % 1 fraction versus 25% and 13%, respectively, after 4 Gy % 5 fractions. Improvement of motor function was observed in 17% of patients after 8 Gy % 1 fraction and 23% after 4 Gy % 5 fractions, respectively.
Proste vsebinske oznake		radioterapija starejši pacienti doziranje preživetje radiotherapy elderly patients dosage survival