Author/Editor		Kenda, R; Fettich, J; Zupančič, Ž
Title		Presejanje asimptomatskih sorojencev otrok z vezikoureternim refluksom
Translated title		Screening of asymptomatic siblings of children with vesicoureteral reflux
Type		članek
Source		Slov Pediatr
Vol. and No.		Letnik 2, št. 1-3
Publication year		1995
Volume		str. 184-7
Language		slo
Abstract		The purpose of the study was to determine the incidence of vesicoureteral reflux (VUR), renal scars and hypertension in asymptomatic siblings of children with VUR. We also wanted to evaluate the benefit of screening older asymptomatic siblings (5-15 years) with ultrasound (US). In the first part of the project, 105 siblings of patients with VUR were studied. Their age ranged from 4 months to 6 years and 4 months. All had a direct radionuclide voiding cystography (DRVC) performed. VUR was detected in 47 from 105 (45 pct.). Most high grade VUR were seen with the first year of age, their incidence being 50 pct. compared with 9 pct. incidence in siblings older than 2 years. Only 1 of the 27 siblings with VUR grade 1 was younger than 1 year. In 43 of 47 siblings with VUR, 99mTc-DMSA was performed and renal scars were found in 10, which represents 23 pct. of siblings with VUR and 10 pct. siblings studied. One child had hypertension. In the second part we performed US in 88 asymptomatic siblings (5 to 15 years old) and failed to detect VUR or any abnormality due to VUR. No child had hypertension. Early identification of VUR among asymptomatic siblings could probably prevent renal damage and its consequences. In identifying VUR, the predictive value of positive family history alone was 45 pct. and 23 pct. of siblings with VUR were found to have renal scars. This appears high enough to justify the routine investigation of asymptomatic siblings by using DRVC at an early age. The study also failed to prove the benefit of US screening of older asymptomatic siblings.
Descriptors		VESICO-URETERAL REFLUX FAMILY CHILD