Avtor/Urednik		Fakin, B
Naslov		Factors contributing to the chronic venous insufficiency
Tip		članek
Vir		Acta Dermatovenerol Alp Pannon Adriat
Vol. in št.		Letnik 4, št. 2
Leto izdaje		1995
Obseg		str. 51-4
Jezik		eng
Abstrakt		Isufficiency - whether retrograde or anterograde - of the venous circulation in the lower extremities causes hemodynamic disturbances. This appear first in the large veins and thence spread to the venous capillaries. A high venous pressure that fails to decline or declines inadequately with muscular activity leads to anatomical and functional changes in the microcirculation: inflammation, edema, a low pO2, stimulation of fibroblasts and collagen formation. Fibrinolytic activity is reduced, and elevated fibrinogen levels in blood result in the formation of fibrin cuffs. The concomitant involvemet of the lymphatic system contributes to the development of lymphedema. All these changes are ultimately manifested in the clinical picture of chronic venous, or venous and lymphatic, insufficiency.
Deskriptorji		VENOUS INSUFFICIENCY VARICOSE VEINS VARICOSE ULCER