Avtor/Urednik		Smet, Stéphanie; Pötter, Richard; Haie-Meder, Christine; Lindegaard, Jacob Christian; Jürgenliemk-Schulz, Ina Maria; Mahantshetty, Umesh; Šegedin, Barbara; Bruheim, Kjesti; Hoskin, Peter J.; Rai, Bhavana
Naslov		Fatigue, insomnia and hot flashes after definitive radiochemotherapy and image-guided adaptive brachytherapy for locally advanced cervical cancer
Tip		članek
Vol. in št.		Letnik 127, št. 3
Leto izdaje		2018
Obseg		str. 440-448
ISSN		0167-8140 - Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology
Jezik		eng
Abstrakt		To evaluate the pattern of manifestation of fatigue, insomnia and hot flashes within the prospective, observational, multi-center EMBRACE study. METHODS: Morbidity was prospectively assessed according to CTCAE v.3 and patient-reported outcome with EORTC QLQ-C30/CX24 at baseline and regular follow-up. Analyses of crude incidence, prevalence rates and actuarial estimates were performed. RESULTS: A total of 1176 patients were analyzed with a median follow-up of 27%months. At baseline, CTCAE G1/G2 prevalence rates for fatigue were 29%/6.2%, for insomnia 18%/3.1% and for hot flashes 7.9%/1.6% with respective 3-year prevalence rates of 29%/6.8%, 17%/4.4% and 19%/5.9%. Similar patterns of manifestation were seen in patient-reported EORTC outcomes. The 3-year actuarial estimates for G%%%3 CTCAE fatigue, insomnia and hot flashes were 5.5%, 4.7% and 1.9%. Younger age was associated with significantly higher risk for fatigue, insomnia and hot flashes. CONCLUSION: Fatigue, insomnia and hot flashes occurred mainly in the mild to moderate range. Fatigue and insomnia were already present before treatment and showed minor fluctuations or recovery during follow-up, whereas hot flashes showed a considerable increase after treatment. More research is needed to evaluate contributing risk factors in order to define intervention strategies.
Proste vsebinske oznake		rak materničnega vratu lokalno napredovali rak utrujenost obsevanje cervical cancer locally advanced cervical cancer fatigue radiotherapy