| Author/Editor | Jurdana, Mihaela | |
| Title | Exercise effects on muscle stem cells | |
| Type | članek | |
| Vol. and No. | Letnik 8, št. 2 | |
| Publication year | 2017 | |
| Volume | str. 125-135 | |
| ISSN | 2232-2620 - Annales kinesiologiae | |
| Language | eng | |
| Abstract | Satellite cells are skeletal muscle stem cells that facilitate muscle repair and regeneration after "damage" which occurs after physiological stimuli: exercise, post-training micro-injuries and electrical stimulation. Exercise stimuli lead to activation and proliferation of these cells from their quiescent state, therefore, increasing cell numbers having the potential to provide additional myonuclei to their parent muscle fibre or return to a quiescent state. Different exercise modalities are the focus of numerous studies on satellite cells activation. An increase in muscle activity augments satellite cells proliferation as well as skeletal muscle mass and function, both in young and elderly. This review provides an updated view of the contribution of skeletal muscle satellite cells in regulating skeletal muscle mass and the efficiency of the exercise intervention to attenuate the decline in muscle mass.Satelitske celice so skeletno-mišične staminalne celice, ki omogočajo popravilo in regeneracijo mišičnih vlaken po mikropoškodbah, kot je telesna aktivnost, trening ali električna stimulacija. Telesna aktivnost sproži prehod satelitskih celic iz stanja mirovanja v aktivacijo in proliferacijo, kar jim omogoča, da se namnožijo in povečajo svoje število. Novonastale satelitske celice se lahko vežejo na matično mišično vlakno ali preidejo v stanje mirovanja. Veliko študij preučuje, kako različne oblike vadbe vplivajo na aktivacijo satelitskih celic ter njihovo število. Znano je, da mišična aktivnost povečuje proliferacijo satelitskih celic, posledično tudi mišično maso in funkcijo, tako pri mladih kakor tudi pri starejših osebah. Pregled literature v tem članku prikazuje posodobljen pogled na vlogo satelitskih celic pri vzdrževanju mišične mase in pomembnost vloge telesno/gibalne aktivnosti v preventivi pred izgubo le-te. | |
| Keywords | satellite cells acute exercises chronic exercises micro damage muscle regeneration satelitske celice akutna vadba kronična vadba mikro poškodbe mišična regeneracija |