| Author/Editor | Miljković, Milica; Stefanović, Aleksandra; Simić-Ogrizović, Sanja; Bogavac-Stanojević, Nataša; Černe, Darko; Kocbek, Petra; Marc, Janja; Jelić-Ivanović, Zorana; Kalimanovska Spasojevič, Vesna; Kotur Stevuljević, Jelena | |
| Title | Association of dyslipidemia, oxidative stress, and inflammation with redox status in VLDL, LDL, and HDL lipoproteins in patients with renal disease | |
| Type | članek | |
| Vol. and No. | Letnik 69, št. 10 | |
| Publication year | 2018 | |
| Volume | str. 861-870. | |
| ISSN | 0003-3197 - Angiology | |
| Language | eng | |
| Abstract | Some cardiovascular complications in patients with chronic kidney disease and end-stage renal disease may be caused by structurally and functionally modified lipoproteins. Redox status (advanced oxidation protein products [AOPPs]), prooxidant- antioxidant balance, total protein sulfhydryl (SH-groups), and paraoxonase 1 (PON1) activity were assessed in 77 renal patients and 20 controls. Lipoproteins were isolated using ultracentrifugation. PON1, PON3, and pentraxin-3 concentration were determined by enzyme-linked immunosorbent assay (ELISA). Dyslipidemia-Oxy-Inflammation (DOI) score was calculated as a sum of dyslipidemia, oxidative stress, and inflammation scores. The dyslipidemia score (P < .001), oxy score (P < .01), inflammation score (P < .001), and the DOI score (P < .001) were higher in patient groups compared with controls. The very-low-density lipoprotein (VLDL) fraction contained the highest amount of AOPP (P < .001) compared with other lipoprotein fractions in all groups. The low-density lipoprotein (LDL) fraction contained elevated AOPP in all groups compared with the high-density lipoprotein (HDL) fraction (P < .001). Significant positive correlation was observed between AOPP in LDL fraction and DOI score (ro = 0.510, P < .01). Dyslipidemia, oxidative stress, and inflammation play an interactive role in renal disease and are mutually associated with redox status in VLDL, LDL, and HDL lipoproteins in plasma of renal patients. | |
| Descriptors | Nefrologija | |
| Keywords | dyslipidemia oxidative stress inflammation paraoxonase lipoproteins |