Author/Editor		Kumer, Kristina; Premru-Sršen, Tanja; Fabjan-Vodušek, Vesna; Tul, Nataša; Fabjan, Teja; Osredkar, Joško
Title		Peripheral arterial tonometry and angiogenic biomarkers in preeclampsia
Type		članek
Vol. and No.		Letnik 37, št. 4
Publication year		2018
Volume		str. 197-203
ISSN		1525-6065 - Hypertension in pregnancy : official journal of the International Society for the Study of Hypertension in Pregnancy
Language		eng
Abstract		Objective: To evaluate changes in vascular function and serum biomarkers in women with and without preeclampsia (PE) to create a model for the easier and more precise diagnosis of PE in the future. Methods: Endothelial function and arterial stiffness were evaluated using peripheral arterial tonometry and concentrations of placental growth factor (PlGF), soluble fms like tyrosine kinase 1 (sFlt-1) and soluble endoglin (sEng) were determined by immunoassay. Results: Arterial stiffness deteriorates and endothelial function is better in women with PE compared with a healthy pregnancy. Women who developed PE had a decreased PlGF and PlGF/(sFlt-1+ sEng) ratio and an increased sEng, and sFlt-1/PlGF ratio. Conclusion: Peripheral arterial analysis did provide additional information beyond serum biomarkers in the diagnosis of PE.
Descriptors		Nosečnostna toksemija
Keywords		angiogenic biomarkers endothelial function peripheral arterial tonometry preeclampsia