Avtor/Urednik		Fabjan, Andrej; Bajrović, Fajko
Naslov		Novel direct anticoagulants and atherosclerosis
Tip		članek
Vol. in št.		Letnik 17, št. 1
Leto izdaje		2019
Obseg		str. 29-34
ISSN		1570-1611 - Current vascular pharmacology
Jezik		eng
Abstrakt		Coagulation factors can affect cellular processes that include inflammatory signaling by acting on endothelial protease activated receptors, vascular smooth muscle and inflammatory cells beyond the coagulation cascade. This is important in the pathogenesis of atherosclerosis. Accordingly, experimental data points to beneficial effects of coagulation protease inhibitors on the attenuation of atherosclerosis progression in animal models. However, available clinical data do not support the use of anticoagulants as an add-on treatment of atherosclerosis. New clinical studies are needed with a better selection of patients to clarify the role of novel direct anticoagulants in the management of atherosclerosis.
Proste vsebinske oznake		atherosclerosis activated factor X coagulation factors ateroskleroza aktivirani faktor X koagulacijski faktorji