Avtor/Urednik | Cvetinović, Nataša; Šekularac, Nikola; Haehling, Stephan; Tahirović, Elvis; Inkrot, Simone; Lainščak, Mitja; Apostolović, Svetlana; Putniković, Biljana; Waagstein, Finn; Gelbrich, Götz | |
Naslov | The [beta]-blocker uptitration in elderly with heart failure regarding biomarker levels | |
Tip | članek | |
Vol. in št. | Letnik 12, št. 11 | |
Leto izdaje | 2018 | |
Obseg | str. 1261-1270 | |
ISSN | 1752-0363 - Biomarkers in medicine | |
Jezik | eng | |
Abstrakt | : We investigated if the baseline value of mid-regional pro-atrial natriuretic peptide (NP), N-terminal pro-B-type NP and copeptin may be helpful in optimizing %-blocker uptitration in elderly patients with heart failure. PATIENTS & METHODS: According to the biomarkers' levels, 457 patients were divided into three subgroups and compared with each other at baseline and 3 months after. RESULTS: All mid-regional pro-atrial NP and N-terminal pro-B-type NP subgroups had significant amelioration of left ventricle ejection fraction and New York Heart Association (NYHA) class after 3 months of %-blocker uptitration (p < 0.001). More prominent improvement of left ventricle ejection fraction and New York Heart Association class was observed in subgroups with lower versus higher NPs levels. CONCLUSION: NPs levels, unlike copeptin levels, might be useful tool for objective selection of elderly heart failure patients who could have the greatest benefit of forced uptitration. | |
Proste vsebinske oznake | kronično srčno popuščanje atrijski natriuretski peptid beta antagonist chronic heart failure pro-atrial natriuretic peptide |