Avtor/Urednik		Hahn, Andreas; Kranz, Georg S.; Küblböck, Martin; Kaufmann, Ulrike; Ganger, Sebastian; Hummer, Allan; Seiger, René E.; Spies, Marie; Winkler, Dietmar; Swaab, Dick Frans
Naslov		Structural connectivity networks of transgender people
Tip		članek
Vol. in št.		Letnik 25, št. 10
Leto izdaje		2015
Obseg		str. 3527-3534
ISSN		1047-3211 - Cerebral cortex (New York, N.Y. : 1991)
Jezik		eng
Abstrakt		Although previous investigations of transsexual people have focusedon regional brain alterations, evaluations on a network level, especially those structural in nature, are largely missing. Therefore, weinvestigated the structural connectome of 23 female-to-male (FtM)and 21 male-to-female (MtF) transgender patients before hormonetherapy as compared with 25 female and 25 male healthy controls.Graph theoretical analysis of whole brain probabilistic tractography networks (adjusted for differences in intracranial volume) showed decreased hemispheric connectivity ratios of subcortical/limbicareas for both transgender groups. Subsequent analysis revealed that this finding was driven by increased interhemispheric lobar connectivity weights (LCWs) in MtF transsexuals and decreased intrahemispheric LCWs in FtM patients. This was further reflected on aregional level, where the MtF group showed mostly increased local efficiencies and FtM patients decreased values. Importantly, these parameters separated each patient group from the remaining subjects for the majority of significant findings. This work complement spreviously established regional alterations with important findings of structural connectivity. Specifically, our data suggest that network parameters may reflect unique characteristics of transgender patients, whereas local physiological aspects have been shown to represent the transition from the biological sex to the actual gender identity.
Proste vsebinske oznake		bipolarna motnja teorija grafov strukturna povezljivost transspolnost graph theory structural connectivity transgender