Avtor/Urednik		Wilhelmsson, Ulrika; Lebkuechner, Isabell; Leke, Renata; Marasek, Pavel; Yang, Xiaoguang; Antfolk, Daniel; Lasič, Eva; Trkov, Saša; Stenovec, Matjaž; Zorec, Robert
Naslov		Nestin regulates neurogenesis in mice through notch signaling from astrocytes to neural stem cells
Tip		članek
Leto izdaje		2019
Obseg		str. str.
ISSN		1047-3211 - Cerebral cortex (New York, N.Y. : 1991)
Jezik		eng
Abstrakt		The intermediate filament (nanofilament) protein nestin is a marker of neural stem cells, but its role in neurogenesis, including adult neurogenesis, remains unclear. Here, we investigated the role of nestin in neurogenesis in adult nestin-deficient (Nes-/-) mice. We found that the proliferation of Nes-/- neural stem cells was not altered, but neurogenesis in the hippocampal dentate gyrus of Nes-/- mice was increased. Surprisingly, the proneurogenic effect of nestin deficiency was mediated by its function in the astrocyte niche. Through its role in Notch signaling from astrocytes to neural stem cells, nestin negatively regulates neuronal differentiation and survival; however, its expression in neural stem cells is not required for normal neurogenesis. In behavioral studies, nestin deficiency in mice did not affect associative learning but was associated with impaired long-term memory.
Proste vsebinske oznake		astrociti mobilnost astrocitov nevronske matične celice astrocytes astrocyte motility neural stem cells