Author/Editor		Gole, Boris; Potočnik, Uroš
Title		Pre-treatment biomarkers of anti-tumour necrosis factor therapy response in Crohn's disease
Type		članek
Vol. and No.		Letnik 8, št. 6
Publication year		2019
Volume		str. 1-21
ISSN		2073-4409 - Cells (Basel, Switzerland)
Language		eng
Abstract		The most prominent treatment for the serious cases of Crohn's disease (CD) are biological tumour necrosis factor (TNF) inhibitors. Unfortunately, therapy nonresponse is still a serious issue in ~1/3 of CD patients. Accurate prediction of responsiveness prior to therapy start would therefore be of great value. Clinical predictors have, however, proved insufficient. Here, we integrate genomic and expression data on potential pre-treatment biomarkers of anti-TNF nonresponse. We show that there is almost no overlap between genomic (annotated with tissue-specific expression quantitative trait loci data) and transcription (RNA and protein data) biomarkers. Furthermore, using interaction networks we demonstrate there is little direct interaction between the proposed biomarkers, though a majority do have common interactors connecting them into networks. Our gene ontology analysis shows that these networks have roles in apoptotic signalling, response to oxidative stress and inflammation pathways. We conclude that a more systematic approach with genome-wide search of genomic and expression biomarkers in the same patients is needed in future studies.
Keywords		Crohn's disease inflammatory bowel disease anti-tumour necrosis factor adalimumab infliximab certolizumab pegol therapy response biomarker