Avtor/Urednik     Verkhratsky, Alexei; Zorec, Robert; Rodríguez Arellano, José Julio; Parpura, Vladimir
Naslov     Neuroglia in ageing
Tip     članek
Vir     In: Neuroglia in neurodegenerative diseases Singapore : Springer
Leto izdaje     2019
Obseg     str. 181-197
ISSN     2214-8019 - Advances in experimental medicine and biology
Jezik     eng
Abstrakt     Ageing reduces the functional capacity of all organs, so does that of the nervous system; the latter is evident in the reduction of cognitive abilities, learning and memory. While the exact mechanisms of ageing of the nervous system remain elusive, it is without doubt that morpho-functional changes in a variety of neuroglial cells contribute to this process. The age-dependent changes in neuroglia are characterised by a progressive loss of function. This reduces glial ability to homeostatically nurture, protect and regenerate the nervous tissue. Such neuroglial paralysis also facilitates neurodegenerative processes. Ageing of neuroglia is variable and can be affected by environmental factors and comorbidities.
Proste vsebinske oznake     astrociti
staranje
mikroglija
astrocytes
ageing
microglia