Author/Editor		Zimmermann, Matthias; Traxler, Denise; Bekos, Christine; Simader, Elisabeth; Mueller, Thomas; Graf, Alexandra; Lainščak, Mitja; Marčun, Robert; Košnik, Mitja; Fležar, Matjaž; Rozman, Aleš; Korošec, Peter
Title		Heat shock protein 27 as a predictor of prognosis in patients admitted to hospital with acute COPD exacerbation
Type		članek
Vol. and No.		Letnik 25
Publication year		2020
Volume		str. 141-149
ISSN		1466-1268 - Cell stress & chaperones
Language		eng
Abstract		Episodes of acute exacerbations are major drivers of hospitalisation and death from COPD. To date, there are no objective biomarkers of disease activity or biomarkers to predict patient outcome. In this study, 211 patients hospitalised for an acute exacerbation of COPD have been included. At the time of admission,routine blood tests have been performed including complete blood count, C-reactive protein, cardiac troponin T and NT-proBNP. Heat shock protein 27 (HSP27) serum concentrations were determined at time of admission, discharge and 180 days after discharge by ELISA. We were able to demonstrate significantly increased HSP27 serum concentrations in COPD patients at time of admission to hospital as compared to HSP27 concentrations obtained 180 days after discharge. In univariable Cox regression analyses, a HSP27 serum concentration >/= 3098 pg/mL determined at admission was a predictor of all-cause mortality at 90 days, 180 days, 1 year and 3 years. In multivariable analyses, an increased HSP27 serum concentration at admission retained its prognostic ability with respect to all-cause mortality for up to 1year follow-up. However, an increased HSP27 serum concentration at admission was not an independent predictor of long-term all-cause mortality at 3 years. Elevated serum HSP27 concentrations significantly predicted short-term mortality in patients admitted to hospital with acute exacerbation of COPD and could help to improve outcomes by identifying high-risk patients.
Descriptors		Pulmonary disease, chronic obstructive Biomarkers Prognosis Mortality HSP27 Heat-shock proteins Kronična obstruktivna pljučna bolezen Biološki označevalci Prognoza Umrljivost Proteini vročinskega šoka HPS27
Keywords		KOPB akutno poslabšanje aktivnost bolezni COPD acute exacerbation disease activity