Avtor/Urednik		Makovec, Matej; Kerin, Klemen; Skitek, Milan; Jerin, Aleš; Klokočovnik, Tomislav
Naslov		Association of biomarker S100B and cerebral oximetry with neurological changes during carotid endarterectomy performed in awake patients
Tip		članek
Vol. in št.		Letnik iss. 4, št. Vol. 49
Leto izdaje		2020
Obseg		str. 285-293
ISSN		1664-2872 - VASA. Zeitschrift für Gefasskrankheiten
Jezik		eng
Abstrakt		Summary. Background: This study attempted to correlate neurological symptoms in awake patients undergoing carotid endarterectomy (CEA) under local anaesthesia (LA) with serum concentration of S100B protein and measurement of cerebral oximetry with near-infrared spectroscopy (NIRS). Patients and methods: A total of 64 consecutive CEAs in 60 patients operated under LA during an 18-month period were prospectively evaluated. A cerebral oximeter was used to measure cerebral oxygen saturation (rSO2) before and after cross-clamping along with serum concentration of the S100B protein. Selective shunting was performed when neurological changes occurred, regardless of NIRS. Neurological deterioration occurred (neurological symptoms group) in 7 (10.9 %) operations. In 57 (89.1 %) operations, the patients were neurologically stable (no neurological symptoms group). Results: The neurological symptoms that occurred after clamping correlated with an increase in the serum level of S100B (P = .040). The cut-off of 22.5 % of S100B increase was determined to be optimal for identifying patients with neurological symptoms. There was no correlation between rSO2 decline and neurological symptoms (P = .675). Two (3.1 %) perioperative strokes occurred. Conclusions: We found a correlation between neurological symptoms and serum S100B protein increase. However, because of the long evaluation time of serum S100B, this monitoring technique cannot be performed during CEA.
Deskriptorji		Kirurgija Nevrologija Carotid stenosis Stenoza karotidne arterije Stroke Možganska kap Endarterectomy, carotid Karotidna endarterektomija Surgery Kirurgija Prevention and control Preprečevanje in nadzor
Proste vsebinske oznake		perioperative stroke prevention neuromonitoring selective shunting