Author/Editor		Wiche, Gerhard; Osmanagic-Myers, Selma; Castañón, Maria J.
Title		Networking and anchoring through plectin
Type		članek
Vol. and No.		, št. Vol. 32
Publication year		2015
Volume		str. 21-29
ISSN		0955-0674 - Current opinion in cell biology
Language		eng
Abstract		Intermediate filaments (IFs) are involved in multiple cellular processes that are essential for the maintenance of cell and tissue integrity as well as response and adaption to stress. Mainly through pathological manifestations in patients and the analysis of genetic mouse models, it became evident that cytolinker proteins of the plakin protein family are essential for many of the functions ascribed to IFs. As discussed in this review, one of them, plectin, affects the assembly properties, interaction potential, compartmentalization, and linkage properties of IFs, making it to a key player for IF functionality. The far reaching consequences of IFs not being well-connected for skin and muscular integrity, migration, and mechanotransduction are highlighted.
Keywords		plektin celični procesi citolinker plectin cellular processes cytolinker