Author/Editor | Manferdelli, Giorgio; Narang, Benjamin J.; Poussel, Mathias; Osredkar, Damjan; Millet, Grégoire P.; Debevec, Tadej | |
Title | Long-term effects of prematurity on resting ventilatory response to hypercapnia | |
Type | članek | |
Vol. and No. | Letnik 22, št. 4 | |
Publication year | 2021 | |
Volume | str. 420-425 | |
ISSN | 1557-8682 - High altitude medicine & biology | |
Language | eng | |
Abstract | Background: This study investigated the resting ventilatory response to hypercapnia in prematurely born adults. Materials and Methods: Seventeen preterm and fourteen full-term adults were exposed to normoxic hypercapnia (two 5-minute periods at 3% and 6% carbon dioxide [CO2] interspersed by 5-minute in normoxia). Pulmonary ventilation () and end-tidal partial pressure of CO2 (Petco2) were measured continuously. Results: No difference in lung function was observed between preterm and full-term adults. Petco2 was lower in preterm than in full-term adults (p < 0.05) during normoxia. During exposure to 3% CO2, both and Petco2 increased in a similar way in preterm and full-term adults. However, at the end of the 6% CO2 period, there was a significantly higher in preterm compared with full-term adults (30.2 ± 7.5 vs. 23.7 ± 4.5 L/min, p < 0.0001), whereas no difference was observed for Petco2 (46.9 ± 2.1 vs. 50.6 ± 2.1 L/min, p = 0.99). Breath frequency was higher in preterm than in full-term adults (17.9 ± 4.0 vs. 12.8 ± 3.5 b/min, p < 0.01) during 6% CO2 exposure. Conclusions: Although data suggest that prematurity results in resting hypocapnia, the exact underlying mechanisms remain to be elucidated. Moreover, preterm adults seem to have increased chemosensitivity to hypercapnia. | |
Keywords | preterm hypercapnia ventilatory response nedonošenček hiperkapnija ventilacijski odziv |