Author/Editor		Tibaut, Miha; Naji, Franjo; Petrovič, Danijel
Title		Association of myocardial infarction with CDKN2B antisense RNA 1 (CDKN2B-AS1) rs1333049 polymorphism in Slovenian subjects with type 2 diabetes mellitus
Type		članek
Vol. and No.		Letnik 13, št. 3
Publication year		2022
Volume		str. 1-8
ISSN		2073-4425 - Genes
Language		eng
Abstract		Background: We examined the role of rs1333049 polymorphism of the CDKN2B Antisense RNA 1 (CDKN2B-AS1) on the prevalence of myocardial infarction (MI) in Slovenian subjects with type 2 diabetes mellitus (T2DM). Methods: A total of 1071 subjects with T2DM were enrolled in this retrospective cross-sectional case-control study. Of the subjects, 334 had a history of recent MI, and 737 subjects in the control group had no clinical signs of coronary artery disease (CAD). With logistic regression, we performed a genetic analysis of rs1333049 polymorphism in all subjects. Results: The C allele of rs1333049 polymorphism was statistically more frequent in MI subjects (p = 0.05). Subjects with CC genotype had a higher prevalence of MI than the control group in the co-dominant (AOR 1.50, CI 1.02-2.21, p = 0.04) and recessive (AOR 1.38, CI 1.09-1.89, p = 0.04) genetic model. Conclusions: According to our study, the C allele and CC genotype of rs1333049 polymorphism of CDKN2B-AS1 are possible markers of MI in T2DM subjects in the Slovenian population.
Keywords		sladkorna bolezen tip 2 miokardni infarkt bolezen koronarnih arterij type 2 diabetes mellitus myocardial infarction coronary artery disease