Author/Editor		Komine, M; Freedberg, IM; Blumenberg, M
Title		The activated keratinocytes
Type		članek
Source		Acta Dermatovenerol Alp Pannon Adriat
Vol. and No.		Letnik 4, št. 4
Publication year		1995
Volume		str. 169-73
Language		eng
Abstract		The passive protective role of epidermal keratinocytes has been appreciated for a long time, but recently another, active role is also gaining prominence. Activated keratinocytes are migratory and produce as well as respond to a cornucopia of cytokines and growth factors. Interleukin IL-1 and members of the epidemal growth factor family initiate and maintain keratinocytes in activated state, respectively. As a marker of activated keratinocytes we use the expression of keratins K#6, and K#16, proteins not found in healthy skin, but found in wound healing, psoriasis, carcinomas etc. The extracellular signals that activate keratinocytes cause intracellular signal transduction cascades to activate transcription factors necessary for the expression of keratins K#6 and K#16.
Descriptors		KERATINOCYTES EPIDERMAL GROWTH FACTOR-UROGASTRONE RECEPTORS, EPIDERMAL GROWTH FACTOR-UROGASTRONE