Author/Editor | Vitas, M; Rozman, D; Komel, R; Kelly, SL | |
Title | Progesterone side-chain cleavage by Paecilomyces lilacinus | |
Type | članek | |
Source | Phytochemistry | |
Vol. and No. | Letnik 40, št. 1 | |
Publication year | 1995 | |
Volume | str. 73-6 | |
Language | eng | |
Abstract | The filamentous fungus Paecilomyces lilacinus converts progesterone to more polar compounds by a side-chain cleavage reaction. We have investigated the role of cytochrome P-40 in this mono-oxygenase reaction and confirmed the involvement of other cytosolic enzymes. The activity was found to be NADPH-dependent and inducible by pre-exposure of mycelium to progesterone. | |
Descriptors | PAECILOMYCES CYTOCHROME P-450 PROGESTERONE HYDROXYLATION |