Author/Editor		Poljak, M; Eri, Ž
Title		Protucitoplazmatska autoantitijela neutrofilnih granulocita (ANCA) u dijagnostici i praćenju toka Wegenerove granulomatoze
Translated title		Anti-neutrophil cytoplasmic autoantibodies (ANCA) in the diagnosis and follow-up of Wegener's granulomatosis
Type		članek
Source		Saopštenja Instituta za plućne bolesti i tuberkulozu Sremska Kamenica
Vol. and No.		, št. 3-4
Publication year		1989
Volume		str. 173-7
Language		ser
Abstract		Weneger's granulomatosis (WG), systemic necrotizing granulomatous vasculitis, is classically diagnosed according to the typical clinical findings and characteristic histological lesions. Lately, the disease is connected with the finding of anticytoplasmatic antibodies against neutrophils (ANCA) in the sera of patients. ANCA are autoantibodies causing a diffuse, granular staining of the cytoplasm of neutrophils using a standard indirect immunofluorescence technique after fixation of the leucocytes with alcohol. Theoretical principles and methodology of the test are shown in the work. High nosologic sensitivity and great specificity of ANCA test in establishing the diagnosis, in assessing the intesity of the disease and monitoring of the response to therapy is comparatively prooved.
Descriptors		WEGENER'S GRANULOMATOSIS SERODIAGNOSIS AUTOANTIBODIES