Author/Editor		Demšar, Franci
Title		Makromolekularna kontrastna sredstva
Translated title		Macromolecular contrast agents
Type		članek
Source		Med Razgl
Vol. and No.		Letnik 35, št. Suppl 2
Publication year		1996
Volume		str. 81-7
Language		slo
Abstract		Macromolecular contrast agents for magnetic resonance imaging can be defined as paramagnetic or supermagnetic substances with a sufficiently high molecular weight, usually over 20,000 daltons. They are produced in such a way that they highlight perfusion and areas with changed endothelial permeability. In order to obtain an optimal macromolecular contrast agent, a systematic study of the biological distribution of the contrast agent, its release, toxicity and stability is required, and a kinetic model should be made for the calculation of capillary permeability.
Summary		Makromolekularna kontrastna sredstva za slikanje z magnetno resonanco lahko definiramo kot paramagnetne ali superparamagnetne snovi z dovolj veliko molekularno težo, po navadi več ko 20.000 daltonov, ki so prvenstveno izdelana, da poudarijo prekrvljenost in predele s spremenjeno endoteliisko prepustnostjo. Da bi dobili optimalno makromolekularno kontrastno sredstvo, je treba izdelati sistematično študijo biološke porazdelitve kontrastnega sredstva, njegove relaksivnosti, toksičnosti, stabilnosti in izdelati kinetični model za izračun kapilarne prepustnosti.
Descriptors		MAGNETIC RESONANCE IMAGING CONTRAST MEDIA MACROMOLECULAR SYSTEMS DTPA