Author/Editor | Petrovič, D; Keber, I; Zorc, M; Peterlin, B | |
Title | I/D polymorphism at the locus for ACE and apo A-I gene promoter polymorphism as risk factors for coronary artery disease in patients with familial hypercholesterolemia | |
Type | članek | |
Source | Pflugers Arch | |
Vol. and No. | Letnik 431, št. 6 Suppl 2 | |
Publication year | 1996 | |
Volume | str. R197-8 | |
Language | eng | |
Abstract | In our study we searched for an association between the insertion/deletion (I/D) polymorphism at the ACE locus as well as apo A-I promoter polymorphism and coronary artery disease (CAD) in patients with familial hypercholesterolemia (FH). 34 FH patients over 40 years were ascertained; 16 patients with CAD were compared with 18 patients without CAD. There was an excess of DD or ID genotype in FH patients with CAD (OR=4.9, CI=1.17-22.17; Fisher exact p=0.012), however, no association between G to A substitution in the promoter region of the apo A-I gene and CAD was found. Our results suggest that the DD/ID genotype at the ACE gene locus might be an important genetic risk factor for CAD in FH patients. | |
Descriptors | HYPERCHOLESTEROLEMIA, FAMILIAL POLYMORPHISM (GENETICS) PEPTIDYL-DIPEPTIDASE A APOENZYMES CORONARY DISEASE RISK FACTORS |