| Avtor/Urednik | Žargi, Miha; Šmid, Lojze; Fajdiga, Igor; Bubnič, Bernarda; Hočevar-Boltežar, Irena | |
| Naslov | Lasersko izzvana fluorescenca pri prepoznavi raka grla | |
| Prevedeni naslov | Laser induced fluorescence in diagnostics of laryngeal cancer | |
| Tip | članek | |
| Vir | Med Razgl | |
| Vol. in št. | Letnik 35, št. Suppl 6 | |
| Leto izdaje | 1996 | |
| Obseg | str. 121-4 | |
| Jezik | slo | |
| Abstrakt | Fluorescence detection using differences in autofluorescence between normal and malignant tissues offers new possibilities of detecting and localizing early laryngeal carcinoma. Fluorescence imaging was performed using a specially designed device that exploits differences of fluorescent properties of normal and cancerous tissues without photodynamic drugs. The fluorescence was induced by helium-cadmium laser, captured by an image intensified camera and displayed on video monitor after previous computerization. Forty patients (in 20 of them malignancy was suspected) were taken in evaluation. Laryngoscopic apperance obtained by standard microlaryngoscopy was compared to fluorescence image, to conputerized fluorescence intensity measurement and to pathohistological findings. The experience from this study shows that autofluorescence laryngoscopy can be a useful complementary method in detecting laryngeal malignancies. | |
| Izvleček | Avtofluorescenca tkiva, izzvana z lasersko svetlobo, brey fotodinamičnih snovi, ponuja nove možnosti za odkrivanje in zamejitev zgodnjih oblik raka v grlu. Opazovanje nam omogoča posebna naprava, katere delovanje temelji na zaznavanju avtofluorescence, ki je različna pri zdravem in malignem tkivu. Fluorescenco vzbudi helij-kadmijev laser, ončutljiva kamera jo po računalniški obdelavi prikaže kot sliko na zaslonu. Opazovali smo 40 bolnikov, med katerimi smo pri dvajsetih sumili na maligno obolenje grla. Vtis, ki smo ga dobili pri mikrolaringoskopiji smo primerjali s fluorescenčno sliko na monitorju, z meritvami jakosti fluorescence in s histopatološkim izvidom opazovanja tkiva. Pridobljene izkušnje kažejo, da je avtofluorescenčna laringoskopija koristna dodatna preiskava pri prepoznavanju rakasih bolezni grla. | |
| Deskriptorji | LARYNGEAL NEOPLASMS LARYNGOSCOPY FLUORESCENCE LASERS |