Avtor/Urednik		Bole-Vunduk, B
Naslov		Predklinične raziskave o protivnetnem in analgetičnem delovanju nabumetona
Prevedeni naslov		Preclinical studies of anti-inflammatory and analgesic activity of nabumetone
Tip		članek
Vir		Farm Vestn
Vol. in št.		Letnik 47, št. 3
Leto izdaje		1996
Obseg		str. 315-8
Jezik		slo
Abstrakt		Nabumetone displays acute anti-inflammatory activity in the carrageenan-induced paw edema in rats and analgetic activity in the writhing test in mice. Its activity in these tests is less than that of naproxen. The oral dose of nabumetone which inhibited acute carrageenan rat paw edema by 50 percent (ED50) was 27.4 mg/kg and 2.8 mg/kg for naproxen. In writhing test in mice we found that the oral dose of nabumetone which inhibited writhing by 50 percent (ED50) was 203.4 mg/kg and 15.9 mg/kg for naproxen, respectively.
Izvleček		S karageninom inducirani edem podganje tace in writhing test pri miši sta pokazala, da deluje nabumeton akutno protivnetno in analgeti?no. Delovanje nabumetona v omenjenih testih je bilo po oralnem vnosu šibkejše od naproksenovega. Doza, ki je zavrla s karageninom in inducirani edem podganje tace za 50 odstotkov (ED50), je znašala 27,4 mg/kg nabumetona oz. 2,8 mg/kg naproksena. Writhing-test pri miši je pokazal, da sta nabumeton v dozi 203,4 mg/kg in naproksen v dozi 15,9 mg/kg 50-odstotno zmanjšala število abdominalnih krčev (ED50).
Deskriptorji		ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL DRUG SCREENING MICE RATS