Avtor/Urednik		Mlinarič-Raščan, I
Naslov		Vloga protein tirozin fosfataze PTP1C v razvoju in delovanju limfocitov T
Prevedeni naslov		The role of the protein tyrosine phosphatase PTP1C in the development and function of T lymphocytes
Tip		članek
Vir		Farm Vestn
Vol. in št.		Letnik 47, št. 4
Leto izdaje		1996
Obseg		str. 379-89
Jezik		slo
Abstrakt		Mutations in the gene encoding protein tyrosine phosphatase PTPlC are known to underlie the autoimmune and immunodeficient phenotype manifested by motheaten (me) and motheaten viable (mev) mice. PTPlC dysfunction is in motheaten mice associated with the T cell hyper-responsivness to in vitro antigen and mitogen stumulation and consequently with the increased production of interleukin-2. This defect, does however not affect T cell ontogeny. The results discussed herein, suggest that PTPl C may function as an inhibitor in signaling pathway coupling the T cell activation to proliferation, thus implying its physiological growth suppresor activity.
Deskriptorji		T-LYMPHOCYTES AUTOIMMUNITY CELLS, CULTURED