Author/Editor		Lipnik-Štangelj, M
Title		Nesteroidne protivnetne spojine: mehanizem delovanja in farmakološki učinki
Translated title		Non-steroidal anti-inflammatory drugs: mechanism of action and pharmacological effects
Type		članek
Source		Farm Vestn
Vol. and No.		Letnik 47, št. 4
Publication year		1996
Volume		str. 425-31
Language		slo
Abstract		Non-Steroidal Anti-inflammatory Drugs (NSAID's) are heterogenious group of drugs of different chemical classes. They are nonspecific in their actions on different tissues. They interact with several non-enzymic and enzymic proteins. All of the pharmacological effects of NSAID's are related to the primary action of the drug-inhibition of arachidonate cyclo-oxygenase. They exhibit three types of inhibition: reversible competitive, irreversible and reversible non-competitive. NSAID's have three major pharmacological effects: anti-inflammatory, analgesic and antipyretic effect. Unwanted effects of NSAID's are common and include gastrointestinal disturbances, renal effects, skin reactions and bone marrow depression.
Descriptors		ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL CYCLOOXYGENASE INHIBITORS ARACHIDONIC ACIDS