Author/Editor		Čižman, Milan; Paragi, Metka; Gubina, Marija; Jovan-Kuhar, Nadja; Kraigher, Alenka; Fišer, Jerneja; Kolman, Jana; Novak, Dušan; Drinovec, Bojan; Harlander, Tatjana; Sabotin, Davorin; Božanić, Vinko; Kunstelj, Lučka; Meštrovič, Ana; Jazbec, Janez; Lešničar, Gorazd; Primožič, Janez; Špegel, Milan
Title		Epidemiologija invazivnih pnevmokoknih okužb pri otrocih v Sloveniji
Translated title		Epidemiology of invasive pediatric infections due to Streptococcus pneumoniae in Slovenia
Type		članek
Source		Zdrav Vestn
Vol. and No.		Letnik 66, št. 4
Publication year		1997
Volume		str. 179-82
Language		slo
Abstract		Background. Streptococcus pneumoniae is a common cause of morbidity and mortality in pediatric and adult patients. Epidemiology of invasive pediatric infections due to Streptococcus pneumoniae in Slovenia is not known. Such data are now important since conjugate pneumococcal vaccines are being developed. Patients and the methods. In a prospective nationwide study children aged 0 to 14 years during 1993 through 1995 were included in whom S. pneumoniae was isolated from blood, cerebrospinal fluid or other normally sterile body site. Results. During 1993-1995 fifty six invasive infections in fifty five children were diagnosed. Bacteremia/sepsis within apparent focus, pneumonia/empyema, meningitis, cellulitis and other focal infections were dound in 56%, 20%, 16%, 4% and 4% respectively. The annual incidence rate was 4.97 per 100,000 children less than 15 years of age (11.9 per 100,000 children younger than 5 years, and 23.9 among those less than 2 years of age). Pneumococcal group/types 14, 19, 23, 4, 6, 18 and 7 compromised 80% of all invasive pneumococcal infections. Conclusions. The study showed lower incidence of invasive pneumococcal infections as compared to the studies published to date. To found out realistic data on morbidity rates more sensitive and practical tests should be used and/or the present available method should be used more frequently.
Summary		Izhodišča. Streptococcus pneumoniae je pogost vzrok zbolevnosti in smrtnosti otrok in odraslih. Epidemiologija invazivnih pnevmokoknih bolezni pri otrocih v Sloveniji ni poznana, je pa zdaj pomembna, ker so razvili konjugirana pnevmokokna cepiva. Bolniki in metode. V prospektivno triletno študijo, ki je zajela vso Slovenijo, smo vključili otroke, stare 0 do vključno 14 let v obdobju januar 1993 do december 1995, pri katerih smo izolirali Streptococcus pneumoniae iz krvi, možganske tekočine ali drugega normalnega sterilnega mesta telesa. Rezultati. V triletnem obdobju smo dokazali 56 invazivnih okužb pri 55 bolnikih. Glede na klinično diagnozo smo ugotovili najpogosteje bakteriemijo ali sepso brez očitnega žarišča v 56%, pljučnico/empiem v 20%, meningitis v 16%, celulitis v 4% in druge žariščne okužbe prav tako v 4%. Letna zbolevnost je bila pri otrocih pod 15 leti starosti 4,97/100.000 otrok, 11,9/100.000 otrok pod 5 let starosti in 23,9/100.000 pod 2 letoma starosti. Pnevmokoki skupin/tipov 14, 19, 23, 4, 6, 18 in 7 tvorijo 80% vseh invazivnih okužb. Smrtnost je bile 3,6% (2 otroka). Zaključki. S študijo smo ugotovili nižjo zbolevnost za invazivnimi pnevmokoknimi okužbami v primerjavi s študijem, ki so objavljeni v literaturi. Da bi dobili bolj zanesljive podatke o zbolevnosti, bi morali uporabljati bolj občutljive in praktične teste in/ali pogosteje iskati vzroke za invazivne okužbe z dosedanjimi metodami.
Descriptors		PNEUMOCOCCAL INFECTIONS STREPTOCOCCUS PNEUMONIAE INFANT, NEWBORN INFANT CHILD, PRESCHOOL CHILD ADOLESCENCE SLOVENIA PROSPECTIVE STUDIES