Author/Editor		Meh, D; Denišlič, M
Title		Nerve fiber dysfunction in type 1 diabetic children: relation to age, duration of the disease and metabolic control
Type		članek
Source		Neurol Croat
Vol. and No.		Letnik 45, št. 2-3
Publication year		1996
Volume		str. 53-65
Language		eng
Abstract		Peripheral nerve fiber function parameters were assessed in 33 type 1 diabetic children without signs or symptoms of peripheral or autonomic neuropathy, and in 69 healthy controls. Motor and sensory conduction studies were performed. Thermal specific threshold, thermal pain and vibratory perception thresholds were measured accompanied with the evaluation of nerve functions. neurophysiological assessed parameters were correlated with age, durtion of the disease, fasting blood glucose level and glycosylated hemoglobin concentration. Fasting blood glucose level and glycosylated hemoglobin concentration were not correlated to any of the neurophysiologic parameters assessed. Age was found to significantly affect peroneal motor conduction velocity (p < 0.01) and sympathetic skin response latency of the foot (p < 0.01), while the duration of diabtes was most evidently related to ulnar distal motor latency (p < 0.01) and sural sensory conduction velocity (p < 0.01). Nerve fibers involvement wa found to be randomly associated with age and duration of the disease yet never with fasting blood glucose level or glycosylated hemoglobin. Various impairments of nerve fibers may contribute to the mixed etiology of diabetic polyneuropathy, found in type I diabetic children.
Descriptors		DIABETES MELLITUS, INSULIN-DEPENDENT NERVE FIBERS PERIPHERAL NERVOUS SYSTEM DISEASES PAIN THRESHOLD CHILD TIME FACTORS SENSORY THRESHOLDS TEMPERATURE VIBRATION COLD BLOOD GLUCOSE HEMOGLOBIN A, GLYCOSYLATED