Avtor/Urednik		Popović, Mara
Naslov		Prionske bolezni pri človeku
Prevedeni naslov		Human prion diseases
Tip		članek
Vir		Med Razgl
Vol. in št.		Letnik 36, št. 2
Leto izdaje		1997
Obseg		str. 181-9
Jezik		slo
Abstrakt		Prion diseases are rare degenerative diseases of the central nervous system in humans and some other mammals. Three different etiopathogenetical forms of these diseases are recognised in humans, being, as such, unique in medical praxis. Results of numerous researches show the existence of prion, proteinaceous infective particle having physical and chemical characteristics of amyloid, as the common causative agent. Prion originates either in central nervous system or is introduced to it from the outside. The occurrence of the new variant of Creutzfeldt-Jakob's disease, the most researched form of the human prion diseases, recently described in Great Britain and France, causes great concern due to the eventual possibility of the transmission of bovine spongiform encephalopathy to humans. The above described put the prion diseases at the unique position, imposing the need of being continuousy informed about the current status of researches to medical students and stuff concerned.
Izvleček		Prionske bolezni so redke degenerativne bolezni osrednjega živčevja človeka in nekaterih drugih sesalcev Pri človeku se pojavljajo v treh različnih etiopatogenetskih oblikah, kar je edinstven pojav v medicini. Mnoge raziskave so pokazale, da je skupni imenovalec teh bolezni prion, beljakovinski kužni delec, ki ima fizikalno-kemične lastnosti amiloida. Prion bodisi nastaja v osrednjem živčevju bodisi pride vanj iz zunanjosti. Pojav nove različice Creutzfeldt-Jakobove bolezni, najbolj raziskane oblike prionske bolezni pri človeku, ki je bila pred kratkim opisana v Veliki Britaniji in Franciji, zbuja precejšnjo zaskrbljenost zaradi morebitnega prenosa povzročitelja te bolezni z goveda na človeka. Zaradi teh lastnosti imajo prionske bolezni posebno mesto v medicinski znanosti, medicinci pa morajo poznati najnovejša dognanja, povezana s to skupino bolezni.
Deskriptorji		PRION DISEASES CREUTZFELDT-JAKOB SYNDROME PRIONS